Zoloft Birth Defects Information Center

The antidepressant sertraline hydrochloride—sold under the brand name Zoloft (and also less commonly as Lustral)—might have caused you and your baby to suffer life-threatening harm. Zoloft causes numerous birth defects, injuries, and other complications usually when taken by an expectant mother during the first trimester of pregnancy.

Anyone taking Zoloft should be aware of the risks. And any woman who became pregnant while taking Zoloft should speak to a doctor immediately, to assess the risks to an unborn child or to discuss treatment for a child born with a defect.

Because of the inadequate warnings given to those prescribed Zoloft, parents of children who were injured before birth are now bringing lawsuits seeking to be compensated for the harms suffered.

Zoloft (sertraline) is a potent selective serotonin reuptake inhibitor (SSRI) manufactured and sold by American pharmaceutical giant Pfizer, Inc. Available by prescription only, the medication is used to treat major depression, obsessive-compulsive disorder, panic disorder, and anxiety disorders. First brought to market in 1991, Zoloft has since become a blockbuster antidepressant: Doctors wrote more than 29 million prescriptions for the drug in 2007, more than any other antidepressant that year.

SSRIs work by preventing certain receptors in the human brain from absorbing serotonin that has already been released. Serotonin helps maintain feelings of well-being, so preventing its re-absorption alleviates negative feelings. Unlike other drugs (such as buproprion–also known as Wellbutrin—for example), SSRIs minimally affect noradrenaline and dopamine, which regulate stress levels. But SSRIs can cause many side effects, most common among them nausea, somnolence, and sexual dysfunction.

Zoloft in particular has been linked to numerous birth defects in children born to mothers who were taking the drug while pregnant. These include: clubbed foot; cleft lip/palate; delayed development; persistent pulmonary hypertension; gastrochisis; heart defects; skull defects; and brain/spinal cord defects. Moreover, Zoloft can cause premature birth or even miscarriage. And a child exposed to Zoloft in utero can experience withdrawal symptoms after birth.

Zoloft Updates

As Featured In

“The Rottenstein Law Group, which represents clients with claims stemming from the severe side effects of the antidepressant Zoloft, has launched a new Web site designed specifically to inform the public about links between the medication and various serious birth defects.”

Read the full story